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John M Hilfinger Selected Research

Prodrugs

4/2014The development of orally administrable gemcitabine prodrugs with D-enantiomer amino acids: enhanced membrane permeability and enzymatic stability.
10/2011Potential of amino acid/dipeptide monoester prodrugs of floxuridine in facilitating enhanced delivery of active drug to interior sites of tumors: a two-tier monolayer in vitro study.
8/2011Tyrosine-based 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine and -adenine ((S)-HPMPC and (S)-HPMPA) prodrugs: synthesis, stability, antiviral activity, and in vivo transport studies.
9/2008Enhanced cancer cell growth inhibition by dipeptide prodrugs of floxuridine: increased transporter affinity and metabolic stability.
7/2008Serine peptide phosphoester prodrugs of cyclic cidofovir: synthesis, transport, and antiviral activity.
6/2008Enhanced absorption and growth inhibition with amino acid monoester prodrugs of floxuridine by targeting hPEPT1 transporters.
11/2007Proline prodrug of melphalan, prophalan-L, demonstrates high therapeutic index in a murine melanoma model.
1/2005Prolidase, a potential enzyme target for melanoma: design of proline-containing dipeptide-like prodrugs.
9/2003Amino acid ester prodrugs of floxuridine: synthesis and effects of structure, stereochemistry, and site of esterification on the rate of hydrolysis.

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John M Hilfinger Research Topics

Disease

6Neoplasms (Cancer)
04/2014 - 01/2005
2Vaccinia
08/2011 - 07/2008
2Cowpox
08/2011 - 07/2008
2Virus Diseases (Viral Diseases)
03/2010 - 07/2008
2Acquired Immunodeficiency Syndrome (AIDS)
03/2010 - 07/2008
2Melanoma (Melanoma, Malignant)
11/2007 - 01/2005
1Herpes Simplex
08/2011
1Cytomegalovirus Retinitis
03/2010
1Retinitis
07/2008
1Weight Loss (Weight Reduction)
11/2007
1Adenocarcinoma
09/2003

Drug/Important Bio-Agent (IBA)

9ProdrugsIBA
04/2014 - 09/2003
3BuffersIBA
04/2014 - 09/2003
3Amino AcidsFDA Link
04/2014 - 09/2008
3DipeptidesIBA
10/2011 - 01/2005
3Cidofovir (Vistide)FDA Link
08/2011 - 07/2008
2Floxuridine (FUdR)FDA LinkGeneric
10/2011 - 09/2008
2Antiviral Agents (Antivirals)IBA
03/2010 - 07/2008
2proline dipeptidase (prolidase)IBA
11/2007 - 01/2005
2Proline (L-Proline)FDA Link
11/2007 - 01/2005
2Melphalan (Alkeran)FDA LinkGeneric
11/2007 - 01/2005
1Dosage Forms (Dosage Form)IBA
04/2014
1GemcitabineFDA Link
04/2014
19- (S)- (3- hydroxy- 2- (phosphonomethoxy)propyl)adenineIBA
08/2011
1Fluorouracil (Carac)FDA LinkGeneric
09/2008
1cyclic- 1- (3- hydroxy- 2- phosphonylmethoxypropyl)cytosineIBA
07/2008
1prophalanIBA
11/2007
1EnzymesIBA
01/2005
1Phenylalanine (L-Phenylalanine)FDA Link
01/2005
1Phosphates (Orthophosphate)IBA
09/2003